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The potential link between microglia activation and CD‐LBP and nociceptive neurite ingrowth was further investigated in a modified disc puncture‐induced degeneration‐related back pain mouse model, using transgenic CX3CR1 GFP/+ mice to fluorescently label microglia in the lumbar spinal cord

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The copper ion is integral to its biological activity, coordinating with the three amino acid residues to form the active complex