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As the primary source of reducing equivalents, NADPH is primarily produced by glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase in the pentose phosphate pathway (PPP)

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In addition, revealing that ferrostatin-1 treatment can mitigate Aβ-related effects on lipid peroxidation, and iron homoeostasis in AD iPSCs-derived brain organoids further supports the hypothesis that in AD, ferroptosis is linked with Aβ pathology