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This holistic perspective provides new insights into the pathogenesis of complex diseases and may lead to more integrated therapeutic approaches that consider the interdependence of the gut, brain, and kidneys (Yang et al., 2018)

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Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to find and to exclude the outliers in the samples of each group to ensure the good repeatability and reliability of data within the treatment