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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J

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Challenges and Considerations in Nasal Spray Compounding While nasal sprays offer many benefits, pharmacists must be mindful of potential challenges in their formulation and use: Rapid Clearance and Short Retention Time : The nasal cavity clears medications quickly due to mucociliary activity, meaning the window for drug absorption is limited