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The major hurdles—lack of objective diagnostic biomarkers, the BBB impeding drug delivery, significant patient heterogeneity, and the need for more sensitive clinical trial endpoints—collectively form a critical barrier to progress

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Improved delivery of the chemotherapeutic irinotecan across the BBB can improve survival time from 29.5 days with free irinotecan to 54.2 days with the liposome in a rat brain tumor model [140]