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Rapamycin (a thioredoxin interacting protein (TXNIP) agonist) treatment also attenuated MCD-induced steatosis, inflammation, and fibrosis with increased TFEB nuclear translocation and restored FAO in TXNIP-KO mice by inhibiting MTORC1 to promote autophagy

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This figure highlights the convergence of multiple TCM interventions on the Keap1/Nrf2/ARE axis, GPX4, SLC7A11, ACSL4, and iron transporters, illustrating the multi-target nature of TCM and guiding future combination strategies