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doi: 10.1038/s41408-017-0039-2 5 WardPSThompsonCB

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Pearson correlation analysis showed that, in T2DM, persistent hyperglycemia induced oxidative stress (elevated MDA and ROS levels) and M1 macrophage polarization, resulting in the release of large amounts of pro-inflammatory cytokines (IL-2, IL-6, TNF-α), which led to impaired liver and kidney function and multi-organ damage