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Organs such as brain and heart, with high rates of oxygen consumption and limited respiration levels, are particularly vulnerable to this phenomenon, hence partially explaining the high prevalence of cardiovascular diseases (CVD) and neurological disorders in elderly (Corbi et al., 2008)

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In their study, the effects of age on TEER was tested using ileal biopsies from healthy humans, young (7–12 years), adult (20–40 years), and aging (67–77 years)