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Here, RMSF values were computed to examine the effect of ligands on protein backbone flexibility (Fig

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The trastuzumab and pertuzumab binding epitopes are located ~60 angstrom (A) apart and the HER2- trastuzumab-pertuzumab complex structure guided the design of the bispecific antibody zanidatamab that interacts with both HER2 epitopes and has improved therapeutic efficacy 62

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