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As far as MCFG resistance is concerned, from our data a role of glutathione metabolism in supporting this condition is not evident

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85 , 86 It was found that cell‐free Hb has a very short circulation lifetime due to the rapid dissociation of the Hb tetramer into dimeric and monomeric forms, which can then bind to plasma immunoglobulins and undergo rapid clearance into the spleen, liver, and kidneys, causing substantial organ toxicity