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The common symptoms of pernicious anemia include: Fatigue, lack of energy, or lightheadedness when standing up or with exertion Pale skin Diarrhea or constipation Nausea, vomiting Loss of appetite Tingling feelings or pain Trouble walking Uncontrollable muscle movements Confusion and memory loss Headaches To diagnose Pernicious Anemia, in addition to a CBC, serum folate, iron, and iron-binding capacity tests can help diagnose pernicious anemia or another type of anemia