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These biomarkers are included in the diagnostic criteria because they can predict both germline and somatic FAS mutations with a post-test probability from 85 to 97% (87% for vitamin B 12 ) and because they are accessible to facilities without the ability to do genetic analysis or functional assays (Teachey et al., 2005

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Nature Medicine Contributors: Jiseung Kang, Hyeon Jin Kim, Min Seo Kim, GBD 2023 Substance Use Collaborators (including Shankargouda Patil), Jae Il Shin, and Dong Keon Yon January 16, 2026 “Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study”