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The liver, as the main site of xenobiotic metabolism, expresses a large repertoire of detoxification genes—cytochrome P450s, phase II enzymes, transporters, and xenobiotic receptors—positioning it as a central interface between the exposome and human health ( 3.2 Examples of external exposomes 3.2.1 External dietary and herbal modulators Dietary constituents and herbal products can markedly influence CYP450 function
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