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“If I keep indulging again and again and again,” she said, “ultimately I have so much on the pain side that I’ve essentially reset my brain to what we call anhedonic or lacking-in-joy type of state, which is a dopamine deficit state.” This is a state in which nothing is enjoyable: “Everything sort of pales in comparison to this one drug that I want to keep doing.” “Just for the record,” Andrew said, smiling, “Dr
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