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This was elucidated by a dramatic increase in the levels of pro-inflammatory cytokines (TNF-α, and IL-1β) along with upregulation of NF-κB/P65 mRNA levels and RAGE inflammation-related genes in the ISO- intoxicated group in comparison to the other groups

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According to the Simons Foundation Autism Research Initiative (SFARI) gene database ( as of November, 2020), there are up to now 284 genetic, 45 pharmacologically-induced, and 8 inbred mouse models of ASD