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Adipocyte-Derived Th2 Cytokines and Myeloid PPARdelta Regulate Macrophage Polarization and Insulin Sensitivity

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For instance, in cells for which maintaining redox homeostasis is more important than nucleic acid synthesis, the PPP is tailored to accelerate the oxidative branch and to direct the nonoxidative branch towards re-synthesizing F6P from pentose phosphate, which is then converted back to G6P to replenish the oxidative branch (Fig