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Mammalian GSTs are a large family that can be further divided into three classes, namely cytosolic GSTs, mitochondrial GSTs, and microsomal GSTs, according to their cellular localizations [2]
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During the first phase, the oxidation of the active site selenol (Se-H) to selenenic acid (Se-OH) pf the GPX4 leads to the reduction of the toxic lipid peroxides to generate the non-toxic lipid alcohols (Figure 4)
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