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For the primary efficacy analysis of actimetry and home diary outcomes, the outcome values were calculated using the measures performed during the planned weeks of assessment (the first and last week of each treatment period) without deviations from the target oral l-dopa dose (that is, a week when the patient did not receive the oral optimized l-dopa dose determined in phase 1 of the DIVE-1 study)
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Another study showed that pregnant women’s exposure to extremely high doses of vitamin B12 could lead to the risk of autism spectrum disorder in an unborn child
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