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Other studies using a transgenic dopaminergic D3 receptor knockout mouse model combined with an α6-GABA A receptor ligand (RO 15–4,513) also showed that increased GABAergic inhibition in the NAc contributes to reducing binge drinking, confirming the critical role of GABAergic neurotransmission in reducing alcohol intake (Leggio et al., 2019)

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Treatment allocation will be coded to prevent unblinding