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Notably, baicalein demonstrated superior efficacy compared to the broad-spectrum deubiquitinating enzyme inhibitor PR-619, positioning it as a more promising candidate drug for USP21-targeted liver cancer therapy, particularly in terms of precisely inhibiting tumor progression and reshaping the immune microenvironment ( + /CD8 + T cells, downregulate PD-L1, and achieve anti-tumor effects ( Baicalin exerts antitumor activity by inducing ferroptosis of tumor cells