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In: Herrmann W, Obeid R, eds

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However, the risk of acute ovarian failure and premature menopause is substantial if treatment includes combined-modality therapy with alkylating agent chemotherapy and abdominal or pelvic radiation therapy or dose-intensive alkylating agents for myeloablative conditioning before HSCT.[50-55] Premature ovarian failure Premature ovarian failure is well documented in childhood cancer survivors, especially in women treated with both an alkylating agent and abdominal radiation therapy.[50,54-57] Studies have associated the following factors with an increased rate of premature ovarian insufficiency (acute ovarian failure and premature menopause): Age at the time of treatment and attained age