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Immunoprecipitation revealed that the N-terminal domain of G6PD interacts with VDAC1 and competes with Bax for binding to VDAC1, alleviating VSMC apoptosis by reducing VDAC1 oligomerization and maintaining the synthetic phenotype of VSMC [110]

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coli, which subsequently led to the identification of TrxR as the NADPH-dependent reductase that recycled Trx-disulfide back to Trx-dithiol to support this reaction [47, 80]

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