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Accordingly, tetra-branched peptides could bind to membrane heparan sulfate proteoglycans or the low density lipoprotein receptor family at sulfated glycosaminoglycan chains or different endocytic receptors respectively though their branched structure which contained human neurotensin (NT4, the sequence is (ELYENKPRRPYIL) 4 ) (Brunetti et al., 2016), were used to conjugate with methotrexate (MTX) for MTX-resistant human breast cancer therapy
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