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Similarly, rats harboring the same DMT1 G185R mutation show reduced susceptibility to 6-hydroxydopamine (6-OHDA)-induced neurotoxicity, with 42.6% dopaminergic neuron loss versus 61.6% in wild-type and 65.9% in heterozygous animals ( Lysosomes serve as dynamic iron reservoirs and key regulators of cellular iron homeostasis
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It is also likely that the effects of TCA cycle manipulation on NADPH production will affect other NADPH-dependent pathways that have been implicated in ER homeostasis—particularly the thioredoxin pathway—in unforeseen ways
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