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Abbreviations BBB: Blood-brain barrier BDNF: Brain-derived neurotrophic factor CRH: Corticotropin releasing hormone FMT: Fecal microbiota transplantation HPA: Hypothalamus-pituitary-adrenal axis IFN-γ: Gamma interferon IgA: Immunoglobulin-A IS: Ischemic stroke MAPK: Mitogen-activated protein kinase TLR-4: Toll-like receptor-4 TNF: Tumor necrosis factor Treg: Regulatory T cells ZO-1: Zonula occludens-1 Declarations Acknowledgement The figures were created with BioRender.com ( Data sharing statement The datasets during the current study are available from the corresponding author on request

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γδT cells are the main subsets that regulate and initiate anti-infection immune responses and secrete a variety of cytokines such as IL-2, IL-3, IL-6, IFN-γ, TNF-α, etc