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However, folate deficiency, either associated or not associated with the thermolabile mutation of the N 5,10 -methylenetetrahydrofolate reductase, and vitamin B 6 deficiency, perhaps associated with cystathionine β-synthase defects or with methionine excess, are believed to be major determinants of the increased risk of cardiovascular disease related to hyperhomocysteinemia

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But once the reductant gives the oxidant the electron, the reductant becomes oxidized and once the oxidant takes an electron it becomes reduced and reluctant to act as an oxidant