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Disadvantages involve higher long-term costs from continuous product consumption, possible adaptation reducing treatment responsiveness over time, psychological dependency on continuous application, and unknown very long-term effects from years of daily copper supplementation

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4.4 Interaction between clinical intervention and pathological mechanisms The preceding sections of this review have systematically elucidated how CKD induces and exacerbates sarcopenia through core mechanisms, including chronic inflammation and oxidative stress, accumulation of uremic toxins, metabolic acidosis, and hormonal dysregulation