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A report has also suggested that gene therapy, specifically with thioredoxin superfamily genes (e.g., Grx2), may serve as a novel avenue for treatment of heart disease (Ahsan et al., Mitochondria are important sites for regulation by S-glutathionylation S-glutathionylation is required to modulate cytoskeletal dynamics, cell motility, cell division, ion transport, calcium homeostasis, gene expression, epigenetics, glycolysis, energy sensing through AMP kinase, bicarbonate metabolism, and apoptosis (Cooper et al., 2012)
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