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Acknowledgements We thank: Yongheng Liang (Nanjing Agricultural University) for plasmid pP 1k GFP-ATG8(406)

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Glutamine input thus supports the overall amino acids pools of the cell to suppress the ISR, which is otherwise activated under amino acid deprivation by the amino acid-sensing kinase GCN2 (encoded by EIF2αK4 ) (Figure 3)