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cisplatin-resistant ovarian cancer cells (A2780 cis) when NAC is administered [23], with NAC having an anti-apoptotic effect, particularly in A2780 cells, by exclusively expressing the apoptotic inhibitor protein XIAP [14] while in A2780 cis cells, NAC primarily inhibits the PTEN/Akt/mTOR pathway through phosphorylation of PTEN and ULK1 to inhibit the autophagy initiation [14] (Figure 1)

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Together, these advances highlight ongoing progress toward defining substate-specific biomarkers that can distinguish harmful from adaptive astrocyte responses to guide therapeutic targeting of astrocyte reactivity in neurological disease