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The release and excessive accumulation of collagen fibers caused by overactivated fibroblasts, which are marked with fibroblast activation protein (FAP), lead to pathological changes in the extracellular matrix (ECM) and persistent inflammation, resulting in a vicious cycle of cellular activity and extracellular fibrosis 3,4,5,6,7
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They are water-soluble, meaning excess amounts are generally excreted through the kidneys, though very high doses of certain B vitamins carry their own risks