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Introduction Hyperhomocysteinemia (HHcy) is an important risk factor for atherosclerosis (AS) and is defined as fasting plasma homocysteine (Hcy) higher than 15 μmol/L ( Endothelial cells (ECs) are located in the innermost layer of blood vessels and form the vascular intima, which is important for maintaining vascular homeostasis and normal blood circulation
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