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The diagnosis of advanced keratoconus was made according to clinical signs (Munson’s sign, Rizutti’s sign) slit-lamp biomicroscopic examination (Vogt’s striae, Fleischer’s ring, apical thinning), corneal topography (skewed asymmetric bow-tie, severe central or inferotemporal steepening, high keratometric power), tomographic signs (abnormal elevation maps, abnormal pachymetry maps, keratoconus detection by Belin/Ambrosio Enhanced Ectasia Display) and refractive results (loss of BCVA)
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