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In contrast, the naked Au NPs, PEG-coated Au NPs and BSA-protected Au NCs with the hydrodynamic diameter of ~6–100 nm have been found with acute liver toxicity, such as the increase of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 37,50,54,55,56

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Actual values for MAP and heart rate before and after injection of NLX in morphine-treated rats receiving infusions of vehicle, L-cysteine, or L-CYSee are shown in Supplementary Table S1