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doi: 10.2174/0125899775373406250411104442 54 Suárez CastroE.Santos-GarcíaD.de Deus FonticobaT.Expósito RuízI.Tuñas GestoC.Macías ArribíM

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Notably 16 , devoid of a macrocyclic ring system in the N-terminal is not selective and inhibits both IRAP and AP-N activity, suggesting that introduction of proper conformational constrains in the N-terminal by macrocyclization improves selectivity (Axén et al., 2007)