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It was first identified in 1973 by biochemist Loren Pickart, who observed that plasma from younger donors caused older liver tissue to resume more youthful metabolic activity

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A ClinicalTrials.gov search conducted on August 16, 2026, did not identify a clearly registered interventional trial evaluating synthetic Epitalon for insomnia, anti-aging treatment, or human longevity under the searched Epitalon and Epithalon terms