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Elevation of glutathione as a therapeutic strategy in Alzheimer disease - ScienceDirect

Preclinical findings in mice frequently do not replicate in humans, particularly in metabolic research, where multiple prior "promising" targets have failed at the human trial stage

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A study indicated that untreated patients with adrenal insufficiency demonstrated increased sleep fragmentation, increased REM latency, and decreased amount of time in REM sleep, findings that may explain the patients' fatigue (54)