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Prodrug strategies have also been employed for peptide therapeutics as has been demonstrated for thyrotropin-releasing hormone[83] and 10β,17α-dihydroxyestra-1,4-dien-3-one, a bioprecursor prodrug that results in enhanced CNS concentrations of 17α-estradiol[84], which indicates the potential for designing prodrugs to achieve improved CNS delivery of therapeutic agents
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