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Predicted physicochemical properties of dihexa | Download Table

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Engineered to isolate the minimal pharmacophore required for potassium channel inhibition, it acts as a potent, highly selective antagonist of the TASK-3 (K 2P 9.1) two-pore domain potassium channel, displaying nanomolar affinity ( IC 50 ≈ 2.5 nM) that significantly surpasses parent spadin sequences