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A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed

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5-Amino-1MQ (5-amino-1-methylquinolinium) is a membrane-permeable, selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT)