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Moreover, the colonic contraction in IBS patients can activate the LC-noradrenergic system, thus, creating a vicious cycle which may explain the chronicity of this condition [275]

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Improving the pharmacokinetics and biodistribution of drugs is one of the primary advantages of surfactant-based DDSs, and they are capable of ensuring that greater amounts of drug are delivered to the tumor site by restricting premature drug release and reducing the agglomeration of hydrophobic drugs [50]