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In addition to triggering apoptosis, ROS also has the potential to reduce melanogenesis, as demonstrated by in vitro tests following exposure of melanocytes to H2O2.48–51 The theory of vitiligo development due to oxidative stress (OS) suggests that ROS production would be induced by multiple intrinsic factors (such as inflammation and protein synthesis), as well as extrinsic ones, such as exposure to ultraviolet radiation pollutants, and phenolic compounds