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66 , 67 Resting‐state functional MRI data acquired from nonspecific CLBP patients at baseline and after a manipulation for back pain intensification implicated a role of the mesocortical and mesolimbic pathways, potentially mediating the contribution of pain sensitization to pain chronification in CLBP

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It is a complex degenerative process involving cartilage loss, subchondral bone remodeling, chronic low-grade inflammation, biomechanics, and pain processing