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It can also improve collagen fiber quality by increasing some structural skin elements (so-called proteoglycans), like decorin and lumican

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Pro-inflammatory cytokines—including IL-1β and TNF-α—activate the extrinsic pathway through death receptor engagement and caspase-8 initiation, while concurrently stimulating ROS and NO production to amplify intrinsic apoptosis (Xiao et al., 2023)