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6.3 Roadmap: crossing the translational gap To translate the experimental potential of natural products into clinical reality, future research should focus on the following three strategic directions: (1) Innovation in Drug Delivery Systems: To address the poor water solubility and rapid metabolism of compounds such as polyphenols, there should be a strong emphasis on developing targeted nano-delivery systems (e.g., mannose-modified liposomes targeting pulmonary macrophages, or chitosan nanoparticles targeting renal tubules)