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α-KG can also be exported to the cytosol to be carboxylated into citrate through isocitrate dehydrogenase 1 (IDH1) and further into acetyl-CoA for de novo fatty acid synthesis (Fendt et al., 2013)

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This formulation allows for repeated use of the same vial over several injections (up to its shelf-life once opened), making it useful for diluting toxins (e.g