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Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells

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An intriguing finding is that f-type TRX is glutathionylated on a cysteine residue external to the active site, decreasing its activity against target proteins such as plastidial NADP-glyceraldehyde3-phosphate dehydrogenase (GAPDH