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49 Other rescue strategies, such as adding on ETV 50 or switching to ETV plus TDF combination therapy, 51 have also been shown to be effective in patients in whom prior NUC therapy has failed and therefore represent alternative treatment options

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(4 R )-4 - Hydroxyochratoxin A ( 24 ), or 4-hydroxyochratoxin A, was isolated from the urine of rats after injection with OTA ( 21 ), which indicated that OTA ( 21 ) was converted to (4 R )-4 - hydroxyochratoxin A ( 24 ) (Figure S8) [29]