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The process pushes lipid mixtures through membranes with specific-sized pores to create uniform vesicles [3]

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All of these perturbations that resulted in ferroptosis in HSCs, increased global ROS levels and lipid peroxidation in the primitive HSC-enriched CD34 + CD45RA − CD90 + compartment (Figure 7C–D), reinforcing the notion that HSC loss in the setting of these perturbations is accompanied by the expected alterations that characterize ferroptosis