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A study using radio-isotopes has confirmed that a large proportion of the ingested probe is in the small intestine during this period ( 51 CrEDTA are resistant to fermentation and can be used to measure total gastrointestinal permeability with longer urine collections up to 24 h ( Figure 2 The Mayo clinic group has proposed the fractional excretion of mannitol, rather than the LMR to evaluate small intestinal permeability ( 13 C mannitol has been suggested as an alternative to the common 12 C mannitol because of the contamination with the latter from food sources in which mannitol is used as a sweetener (e.g., chewing gum) ( The truth of the matter is that the permeability pathways of many of the probes are still unclear